KEMM01 Organic Chemistry - Advanced Course is replaced by KEMM21 Advanced Organic Chemistry from spring term 2020.
The aim of the course is to give advanced knowledge in synthetic organic chemsitry and knowledge in physical organic chemistry
Knowledge and understanding
Be able to identify and and name important organic reactions.
Be able to in detail explain the outcome of organic reactions.
Be able to plan and evaluate multi-step organic reaction sequences using elementar retrosynthetic analysis
Be able to describeorganic chemical reactions in terms of frontier orbital analysis
Be able to discuss orally and in writing organic reactions with regrad to mechanisms and selectivity
Be able to suggest alternative reagents and reactions for performing desired organic transformations
Be able to suggest methods to investigate mechanims of reactions
The course deals primary with organic chemical reactions for the creation of C-C bonds emphasising enolate chemistry but also using pericyclic reactions and radical chemistry. The course gives also advanced knowledge in oxidations and reduction reactions in organic chemistry. The emphasis is on the different chemo-, regio- and diastereoselectivity of the different reaction types. Fundamental retrosynthetic anlysis of target molecues is taught as means to design mutistep synthesis. The course is foucsed on applying a mechanistic approach to understand the outcome of chemical reactions and to emphasise this, the ractions are analyzed using basic forntier orbital analysis. A large part of the course treats methods to elucidate mechansims of reactions such as linear free enery relationships and the primary isotope effect.
An important aspect of the course is to orally present organic reactions to other students. The role of organic chemsitry and in metaril science will be presented.
The laborations are mandatory and are aiming at the illustration of parts of the theoretical contents of the course as well as teaching advanced experimental methodology. Emphasis is given to independence in the planning of each experiment, analysis of the products and critical judgement of literatur syntheses.